Depression will soon become the world’s second – largest cause of disability. People however, use particular amount of stress and depression, relieving agents like that of CBD available in marijuana packaging to get out of an extreme stage of depression.  There is also a vitamin responsible for decreasing depression in an individual, termed as Folate. Folate is a vitamin need for the formation of red blood cells, the metabolism of proteins, cell growth and division, and the prevention of neural tube defects, among other things. Besides anemia and other health problems, folate deficiency can lead to major depressive disorder. Similarly, poor response to antidepressant drugs is associate with either a folate deficiency or other nutritional problems.

Depression can be knock  out with circular breathing and other breathing exercises. But folate prove to act gradually to treat or prevent the depression. Depression is associate with low levels of folate. Folate is easily inactivate by cooking and processing food, and many other factors, including chronic disease, diabetes, and other metabolic problems, cancer, smoking, alcohol use, poor diet, and drugs such as mood stabilizers, can affect folate levels.

HOW FOLATE WORKS TO ELIMINATE DEPRESSION?

The role of the folate in Transmethylation reactions can be traced to the importance of folate in depression. The relationship between folate and depression is also supported by observations that a common genetic variant of an enzyme is more common in patients with depression, which reduces a person’s ability to convert folic acid to L-methyl folate. This means the genetic anomaly would affect reactions to transmethylation and, by extension, synthesis of neurotransmitters.

Homocysteine is an amino acid synthesis toxic intermediate and is an amino acid not used in the production of proteins. It is made of methionine and transformed into its homolog, cysteine. Both homocysteine conversion and recycling back to methionine require B vitamins such as folic acid. The toxic intermediate increases oxidative stress especially in the bones, heart, and central nervous system when low folate levels promote the accumulation of homocysteine.

Homocysteine is responsible in the brain for types of neurological damage that may cause depression. With regard to the effect of folate on standard antidepressants, there is no conclusive evidence that low levels of folate cause poor response to antidepressant therapy. Other studies suggest that for better treatment outcomes a high level of folate can be use.

DECREASED RISK OF DEPRESSION WITH FOLATE:

Low folate status was associate with an increase risk of depression and poor response to treatment with antidepressants. In people with epilepsy, the folic acid deficiency was associate with depression, and one study suggest that nutrient supplementation could help treat low mood. Supplementation with folic acid was not suggeste as a depression treatment in itself, but it may be helpful in improving the response to antidepressants such as fluoxetine, particularly in women.

DEPRESSION CAN LEAD TO HEART DISEASES:

Folate helps in reducing the risk of heart diseases that are a result of depression or anxiety. Heart disease is a complex disorder that includes numerous variables and factors all of which play a different role in development. High levels of a protein known as homocysteine are among these causes, making blood vessels inflexible and resistant to change. This may exacerbate hypertension and increase the risk of coronary artery disease or strokes suffering significantly. Folate is convert into a tetrahydrofolate metabolite that breaks down homocysteine into the beneficial methionine protein. Methionine promotes heart health in sharp contrast to homocysteine.

IT CONTROLS OUR MOOD:

Dopamine and serotonin are the two most important neurotransmitters that control our mood and motivation. Due to a combination of external and individual factors, their levels may change. Usually, when this happens, the result is some manifestation of depressive illness or loss of motivation and life pleasure. Low folate levels are one of these causes, as this vitamin involves both serotonin and dopamine synthesis. Increased consumption of folate not only increases productivity but also stimulates the brain’s serotonin receptors and may enhance the action of medication used to treat depression.

CONCLUSION:

Folate helps the body create new cells and helps to regulate serotonin. Serotonin transmits messages between nerve cells and helps the brain manage a variety of functions, from mood determination to social behavior regulation. In addition to lowering serotonin levels, folate deficiency may cause depression. Folate has the added advantage of boosting antidepressant efficiency. Which appears to be well tolerated in the body. These supplements can consider from the start of treatments of patients suffering from depression or having folate deficiency.

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